GTAV has three main characters: Michael (narrator of the first trailer), Franklin (driver of the red convertible), and Trevor - these are the three who rob the jewelry store, and we come to find out that heists are what they do best (and often). You can switch fluidly (with Google Earth-styled effects) between the three characters at nearly any time, as each is living simultaneously within the city. Every time you switch you will be dropped into the other character's current location and activity. Each of them has their own personality, motivations, skillset, and story. Some missions will even allow you to switch characters during the mission to complete it from a different perspective.
Driving cars now feels less "boatlike", and their handling gives the vehicles of GTAV more of a racing game feel. There are a huge variety of cars, trucks, bikes, helicopters, planes, ATVs, and jet skis - more vehicles than any other GTA to date. Planes will be available early on, and some cars we spotted were the Pfister Comet, the F620, Patriot, 9F, and a Mustang look-alike that could very well be a modern Stallion.
When you include the interior and exterior areas on the map of Los Santos, it is bigger than GTAIV, Red Dead Redemption, and San Andreas combined, and includes beachfronts, underwater coastline, wine country, large wilderness areas, a fully explorable Mount Chiliad, and a military base.
There are a lot more dynamic events (like we said there should be). You can pull over next to a hitchhiker, or a broken down car, and interact with the pedestrian. You may even see 2 parked cars and a sea of dead bodies in the middle of the desert, which you can investigate if you wish. You can hijack random cash trucks, or even stop criminals who stole some lady's purse.
Several complex, multi-tiered missions similar to GTAIV's "Three Leaf Clover" are featured, as heists are a big theme in the game. A greater degree of side missions are available as well as more sophisticated mini-games. Each character has their own unique hobbies. Los Santos has a "very vibrant and fun economy" - there is no property to buy, but "there will be loads of other stuff" - what, exactly, we don't know yet. Ammunation returns, and there was no mention of car customization.
The musical score compliments tense situations, similar to Max Payne 3. Rockstar did not want to use celebrity voice actors, as being able to recognize the voice would detract from the realism of the characters.
The physical copy of this issue of Game Informer will hit news stands on November 16th, and the second Grand Theft Auto V trailer will be revealed on the 14th. If you haven't already done so, go buy new pants.